NEFM; NF-M; NFM; Neurofilament,Medium Polypeptide; 160 kDa neurofilament protein; Neurofilament triplet M protein
Species:
Human
Sample type:
serum, plasma, tissue homogenates, cerebrospinal fluid or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
4741
UniProt ID:
P07197
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
