CCL2; GDCF2; HC11; HSMCR30; MCAF; MCP1; SCYA2; SMC-CF; Chemokine C-C-Motif Ligand 2; Monocyte Chemotactic And Activating Factor; Monocyte Secretory Protein JE
Species:
Dog
Sample type:
serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
403981
UniProt ID:
P52203
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables BH3 domain binding activity. Involved in extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of apoptotic process; and positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; blastocyst; central nervous system; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung cancer; and lung non-small cell carcinoma. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member).
