Enables several functions, including ATP binding activity; extracellularly ATP-gated monoatomic cation channel activity; and lipopolysaccharide binding activity. Involved in several processes, including bleb assembly; negative regulation of cell volume; and positive regulation of NLRP3 inflammasome complex assembly. Acts upstream of or within several processes, including phospholipid transport; positive regulation of cytokine production; and positive regulation of secretion. Located in several cellular components, including external side of plasma membrane; neuromuscular junction; and neuronal cell body. Is expressed in brain; cerebral cortex ventricular layer; heart; and metanephros. Orthologous to human P2RX7 (purinergic receptor P2X 7).
