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TLK1
| Product Category: | Human lentivirus expressing TLK1 |
| Description: | Premade lentivirus for over-expression of human TLK1 and control, ready to use format. |
| Gene Name: | tousled like kinase 1 |
| Gene Symbol: | TLK1 |
| Synonyms: | PKU-beta |
| ACCN: | NM_001136554.2 |
| Gene ID: | 9874 |
| Vector: | VP004-CMV-MCS-3×Flag-EF1-fLUC-T2A-PURO |
| Fusion Tag: | Flag |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
