tissue homogenates, cell lysates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
13805
UniProt ID:
Q63961
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables protein homodimerization activity and transforming growth factor beta binding activity. Involved in several processes, including circulatory system development; positive regulation of cell differentiation; and regulation of gene expression. Acts upstream of or within angiogenesis; cell migration involved in endocardial cushion formation; and positive regulation of angiogenesis. Located in endothelial microparticle. Is expressed in several structures, including aorta-gonad-mesonephros; brain; cardiovascular system; extraembryonic component; and liver. Used to study arteriovenous malformations of the brain and hereditary hemorrhagic telangiectasia. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; hemangioma (multiple); and hereditary hemorrhagic telangiectasia. Orthologous to human ENG (endoglin).
