GK; GLK; HHF3; HK4; HKIV; HXKP; MODY2; Hexokinase-D; Hexokinase 4; Maturity Onset Diabetes Of The Young 2
Species:
Mouse
Sample type:
serum, plasma, tissue homogenates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
103988
UniProt ID:
P52792
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables glucokinase activity. Involved in calcium ion import; intracellular glucose homeostasis; and positive regulation of insulin secretion. Acts upstream of or within several processes, including NADP metabolic process; carbohydrate phosphorylation; and regulation of insulin secretion. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Used to study familial hyperinsulinemic hypoglycemia 3; hyperinsulinemic hypoglycemia; maturity-onset diabetes of the young type 2; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple) and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase).
