serum, plasma, tissue homogenates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
14812
UniProt ID:
Q01097
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables AMPA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in long-term memory; receptor internalization; and synapse assembly. Acts upstream of or within cellular response to ammonium ion; chemical synaptic transmission; and long-term synaptic depression. Located in several cellular components, including dendrite membrane; neuron spine; and perisynaptic space. Part of AMPA glutamate receptor complex. Is active in excitatory synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study schizoaffective disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal recessive intellectual developmental disorder 76; and epilepsy. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1).
