AN; AN2; MGDA; WAGR; Oculorhombin; Aniridia,Keratitis; Aniridia type II protein
Species:
Mouse
Sample type:
tissue homogenates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
18508
UniProt ID:
P63015
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables NAD+-protein ADP-ribosyltransferase activity and chromatin binding activity. Involved in several processes, including decidualization; negative regulation of adipose tissue development; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and negative regulation of interleukin-17 production. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is active in chromatin; nucleus; and site of DNA damage. Is expressed in several structures, including brain; gonad; hemolymphoid system; intestine; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1).
