| Detection range: | 0.781-50ng/mL |
| Sensitivity: | 0.31ng/mL |
| Type: | Traditional PKCα ELISA kit |
| Synonyms: | PRKCA; PKC-A; AAG6; PKC-Alpha |
| Species: | Mouse |
| Sample type: | tissue homogenates or other biological fluids. |
| Experimental method: | Sandwich |
| Shelf life: | 12 months |
| Gene ID: | 18750 |
| UniProt ID: | P20444 |
| Components: | 1. Pre-coated, ready to use 96-well strip plate 1 2. Plate sealer for 96 wells 2 3. Standard 2 4. Diluents buffer: 1×45 mL 5. Detection Reagent A: 1×120 μL 6. Detection Reagent B: 1×120 μL 7. TMB Substrate: 1×9 mL 8. Stop Solution: 1×6 mL 9. Wash Buffer (30× concentrate): 1×20 mL |
Background
Enables calcium,diacylglycerol-dependent serine/threonine kinase activity; integrin binding activity; and lipid binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of bone resorption; and positive regulation of dense core granule biogenesis. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of signal transduction; and regulation of protein phosphorylation. Located in several cellular components, including cone photoreceptor outer segment; intercalated disc; and ooplasm. Part of alphav-beta3 integrin-PKCalpha complex. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha).
