SLC6A2; NAT1; NET; NET1; Sodium-dependent noradrenaline transporter; Noradrenaline Transporter; Solute Carrier Family 6 member 2; Neurotransmitter transporter; Noradrenalin
Species:
Mouse
Sample type:
tissue homogenates, cell lysates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
20538
UniProt ID:
O55192
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables protein-macromolecule adaptor activity. A structural constituent of postsynaptic intermediate filament cytoskeleton. Involved in intermediate filament bundle assembly; postsynaptic modulation of chemical synaptic transmission; and regulation of synapse maturation. Acts upstream of or within several processes, including cytoskeleton organization; neuron projection development; and regulation of axonogenesis. Located in axon and neurofilament. Is active in several cellular components, including Schaffer collateral - CA1 synapse; cholinergic synapse; and intermediate filament cytoskeleton. Is expressed in several structures, including alimentary system; central nervous system; eye; limb; and peripheral nervous system ganglion. Used to study Charcot-Marie-Tooth disease type 2E. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); amyotrophic lateral sclerosis; and invasive ductal carcinoma. Orthologous to human NEFL (neurofilament light chain).
