CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2; Cytokine-inducible SH2 protein 2; STAT-induced STAT inhibitor 2
Species:
Mouse
Sample type:
tissue homogenates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
216233
UniProt ID:
O35717
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables growth hormone receptor binding activity and phosphorylation-dependent protein binding activity. Involved in negative regulation of growth hormone receptor signaling pathway. Acts upstream of or within several processes, including mammary gland development; negative regulation of receptor signaling pathway via JAK-STAT; and positive regulation of neuron differentiation. Predicted to be located in cytoplasm. Predicted to be part of Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including leg; retina; spleen; testis; and ureteric tip. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2).
