serum, plasma, tissue homogenates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
74499
UniProt ID:
Q99P68
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Predicted to enable several functions, including BMP binding activity; DNA-binding transcription factor binding activity; and carbohydrate binding activity. Acts upstream of or within negative regulation of ossification; negative regulation of signal transduction; and ossification. Predicted to be located in Golgi apparatus. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Is expressed in several structures, including arterial system; jaw; limb bud; nervous system; and skeleton. Used to study SOST-related sclerosing bone dysplasia and sclerosteosis 1. Human ortholog(s) of this gene implicated in autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin).
