tissue homogenates, cell lysates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
24408
UniProt ID:
P35439
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables several functions, including enzyme binding activity; signaling receptor binding activity; and transmitter-gated monoatomic ion channel activity. Involved in several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; endosome membrane; and neuronal cell body membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Used to study cocaine dependence; hyperhomocysteinemia; morphine dependence; and withdrawal disorder. Biomarker of several diseases, including alcohol use disorder; amphetamine abuse; brain disease (multiple); cocaine abuse; and drug dependence (multiple). Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal recessive intellectual developmental disorder 76; and epilepsy. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1).
