JAKL; L-JAK; LJAK; A Protein Tyrosine Kinase,Leukocyte; Leukocyte janus kinase; Tyrosine-protein kinase JAK3
Species:
Rat
Sample type:
tissue homogenates, cell lysates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
25326
UniProt ID:
Q63272
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables several functions, including insulin receptor substrate binding activity; phosphatidylinositol 3-kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of apoptotic process; and regulation of biosynthetic process. Located in euchromatin. Is active in glutamatergic synapse and postsynapse. Used to study several diseases, including hyperuricemia; liver disease (multiple); retinal detachment; thrombocytosis; and transient cerebral ischemia. Biomarker of atherosclerosis; gastrointestinal system cancer (multiple); heart disease; liver cirrhosis; and obesity. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2).
