CK1; EHK1; K1; KRT1A; KRT1-A; Cytokeratin 1; Epidermolytic Hyperkeratosis; Keratin, type II cytoskeletal 1; 67 kDa cytokeratin; Type-II keratin Kb1
Species:
Rat
Sample type:
serum, plasma, tissue homogenates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
300250
UniProt ID:
Q6IMF3
Component:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Predicted to enable carbohydrate binding activity and protein heterodimerization activity. Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including complement activation, lectin pathway; keratinization; and protein heterotetramerization. Predicted to act upstream of or within establishment of skin barrier and negative regulation of inflammatory response. Predicted to be located in cytoplasm and membrane. Predicted to be active in cornified envelope and keratin filament. Human ortholog(s) of this gene implicated in KRT1-related nonepidermolytic palmoplantar keratoderma; epidermolytic hyperkeratosis; epidermolytic hyperkeratosis 1; epidermolytic palmoplantar keratoderma 2; and keratosis palmoplantaris striata 3. Orthologous to human KRT1 (keratin 1).
