SIR2L3; Silent Mating Type Information Regulation 2 Homolog 3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; SIR2-like protein 3; Regulatory protein SIR2 homolog 3
Species:
Rat
Sample type:
tissue homogenates, cell lysates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
293615
UniProt ID:
B2RZ31
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables NAD-dependent protein lysine deacetylase activity and tubulin deacetylase activity. Involved in several processes, including regulation of nervous system development; regulation of postsynaptic neurotransmitter receptor internalization; and tubulin deacetylation. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Is active in glutamatergic synapse. Used to study high grade glioma and metabolic dysfunction-associated steatotic liver disease. Biomarker of cocaine dependence and intermittent claudication. Orthologous to human SIRT2 (sirtuin 2).
