| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | CD59a antigen |
| Gene Symbol: | Cd59a |
| Synonyms: | Cd59; MACIF; MAC-IP |
| Gene ID: | 12509 |
| UniProt ID: | O55186 |
| Clone ID: | 9J10H2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-96 of mouse CD59a (NP_031678.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Cd59a antibody |
Background
Predicted to enable complement binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of fibroblast growth factor production; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within negative regulation of activation of membrane attack complex. Located in external side of plasma membrane. Is expressed in several structures, including Meckel's cartilage; nervous system; neural retina; skeleton; and testis. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)).
Images
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Flow cytometry:1×10^6 293F cells(negative control,left) and 293F(Transfection,right) cells were surface-stained with ABflo® 488 Rabbit anti-Mouse CD59a mAb(A23361,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line).Non-fluorescently stained cells was used as blank control (red line). |
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Flow cytometry:1×10^6 293F(Transfection) cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 488 Rabbit anti-Mouse CD59a mAb(A23361,5 μl/Test,right). |