Methoxypolyethylene glycol carboxyl (mPEG-COOH) is a high-quality PEG reagent featuring a reactive carboxyl group (-COOH) at its terminal site. This carboxyl group selectively reacts with amino groups in the presence of peptide coupling reagents such as NHS, DDC, or EDC at pH 7–8.
Polyethylene glycol (PEG) compounds are generally biocompatible, non-toxic, and stable in both organic and aqueous solutions, making them widely used in biological applications, as well as in nanotechnology and materials research. Proteins modified with PEG chains or compounds encapsulated in PEGylated liposomes exhibit a longer in vivo half-life compared to their non-PEGylated counterparts—a phenomenon known as PEG shielding.
Specifications
1. Chemical Name: mPEG-COOH
2. Form: White solid
3. Purity: >97%
4. Molecular Weight: 2000
Component
1. mPEG-COOH: 1 g
Storage
Store at -20°C
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