mRNA-LNP (Messenger RNA-Lipid Nanoparticle) therapeutics involve encapsulating fragile mRNA strands within fatty, microscopic spheres. This delivery vehicle protects the mRNA from degradation and helps it cross cell membranes, allowing the body's own cells to manufacture specific proteins that treat or prevent diseases.

Lipid nanoparticles (LNPs) have emerged as significant candidates for mRNA delivery in immunotherapy, providing both protection to the mRNA and enhanced intracellular delivery efficiency. LIFESCT offers a list of key reagents and kits for mRNA-LNP vaccine reserach.
 

Modified Nucleoside-5′-Triphosphates

Base modified NTPs have been widely used for synthesis of modified mRNA to improve stability and reduce immunogenicity.

Product Name	Cat. #	Price	View
N1-Methyl-UTP (10 µl)	M0154	$99
Pseudo-UTP (10 µl)	M0155	$99
5-Methyl-CTP (10 µl)	M0156	$99

Lipid Nanoparticles (LNPs)

Lipid nanoparticles (LNPs) are the most clinically advanced non-viral gene delivery system. Lipid nanoparticles safely and effectively deliver nucleic acids, overcoming a major barrier preventing the development and use of genetic medicines.

Product Name	Cat. #	Price	View
SM-102 (50 mg)	M0157	$379
ALC-0315 (50 mg)	M0158	$419
ALC-0159 (500 mg)	M0159	$1299
DMG-PEG2000 (500 mg)	M0160	$109
DSPC (500 mg)	M0161	$109
DOPE (500 mg)	M0162	$389
LNP-102 (1 ml)	M0163	$169
LNP-0315 (1 ml)	M0164	$169
mPEG-COOH (50 mg)	M0165	$139

mRNA-LNP Related Products

Product Name	Cat. #	Price	View
LiQuta™ RiboGreen RNA Assay Kit (50 mg)	M0135	$299
T7 RNA Polymerase ELISA Kit (96 T)	M0172	$1399
Double-stranded RNA (dsRNA) ELISA Kit (96 T)	M0173	$1589
T7 RNA Polymerase (20000 U)	M0169	$269
DNase I (5000 U)	M0170	$229
Pyrophosphatase (100 U)	M0171	$459
Murine RNase Inhibitor (4000 U)	M0174	$129
dsRNA-unmodified Standard (50 μl)	M0175	$389
dsRNA-Pseudouridine-U (200 μl)	M0176	$389
dsRNA-N1-me-Pseudo-U (200 μl)	M0177	$389
Poly(A), Polyadenylic Acid (100 mg)	M0150	$129